Chemomicrobiome analysis of lithium ascorbate and other organic lithium salts

Lithium salts are used in medicine as normotimics. An important aspect of the action any medicine, incl. lithium is their effect on human microbiota (microbiome). This work presents results a comparative chemomicrobiome analysis organic salts: ascorbate, comenate, nicotinate, oxybutyrate, aspartate and orotate, carried out using modern technologies for “big data”. For each studied salts, estimates values area under growth curve (AUC) were obtained representative sample microbiota, which included 38 commensal bacteria (including various species bifidobacteria lactobacilli) minimum inhibitory concentrations (MIC) 120 pathogenic bacteria. On average, over ascorbate supported all to somewhat greater extent (AUC = 0.57 ± 0.15) than comenat 0.47 0.17), nicotinate 0.45 0.22), oxybutyrate 0.22 0.31 0.14) orotate 0.50 0.21). In case pathogens, MIC significantly lower (4.50 3.69 μg/ml) (6.31 5.58 μg/ml), (10.98 9.37 (7.45 4.73 (6.37 4.71 (7.27 5.81 μg/ml). Thus, more effective supporting positive other three characterized by certain antibacterial properties against At same time, ubiquitous carbonate, does not contain fragments molecules, will have state microbiota.